| spaSpanishespañol | spa | Indo-European | +24 | 555.6 m | 1 · National |
| vecVenetianŁéngua vèneta | vec | Indo-European | +5 | 2 m | 5 · Developing |
| qucK’iche’Qatzijobʼal | quc | Central American Indian languages | | 2 m | 4 · Educational |
| yidYiddishיידיש | yid | Indo-European | +26 | 1 m | Definitely endangered |
| zapZapotec | zap | Central American Indian languages | | 777,000 | |
| yuaYucatec Mayamàaya t'àan | yua | Central American Indian languages | | 706,000 | 5 · Developing |
| rmyVlax RomaniRomani | rmy | Indo-European | +23 | 538,480 | 6b · Threatened |
| cakKaqchikelKaqchikel Chʼabʼäl | cak | Central American Indian languages | | 500,000 | 4 · Educational |
| tzoTzotzilBats'i k'op | tzo | Central American Indian languages | | 350,000 | 6b · Threatened |
| ctuCh’ol | ctu | Central American Indian languages | | 180,000 | 5 · Developing |
| tszPurepecha | tsz | — | | 175,000 | 5 · Developing |
| husHuastec | hus | Central American Indian languages | | 150,000 | 5 · Developing |
| nguGuerrero Nahuatl | ngu | Uto-Aztecan | | 150,000 | 6a · Vigorous |
| puaWestern Highland Purepecha | pua | — | | 140,000 | 5 · Developing |
| ixlIxil | ixl | Central American Indian languages | | 92,000 | 4 · Educational |
| zaiIsthmus Zapotecdiidxazá | zai | Central American Indian languages | | 85,000 | 5 · Developing |
| hchHuichol | hch | Uto-Aztecan | | 47,625 | 5 · Developing |
| cacChujKoti' | cac | Central American Indian languages | | 43,370 | 5 · Developing |
| nhnCentral Nahuatl | nhn | Uto-Aztecan | | 40,000 | 6b · Threatened |
| mfyMayo | mfy | Uto-Aztecan | | 39,000 | 8a · Moribund |
| poiSierra Popoluca | poi | Mixe–Zoque | | 36,000 | 5 · Developing |
| jacJakaltek | jac | Central American Indian languages | | 33,000 | 5 · Developing |
| zabGuelavía Zapotec | zab | Central American Indian languages | | 28,000 | 5 · Developing |
| maaTecóatl Mazatec | maa | — | | 18,900 | 6a · Vigorous |
| oodO'odhamTohono O’otham | ood | Uto-Aztecan | | 15,000 | 6b · Threatened |
| apwWestern Apache | apw | Na-Dene | | 13,445 | 6b · Threatened |
| xtmPeñasco Mixtec | xtm | — | | 7,400 | 6b · Threatened |
| mtoTotontepec Mixe | mto | Mixe–Zoque | | 5,500 | 5 · Developing |
| nhgTetelcingo Nahuatl | nhg | Uto-Aztecan | | 3,500 | 6b · Threatened |
| vmmMitlatongo-Yutanduchi Mixtec | vmm | Central American Indian languages | | 2,800 | 6a · Vigorous |
| zavYatzachi Zapotec | zav | Central American Indian languages | | 2,500 | 6b · Threatened |
| varHuarijio | var | Uto-Aztecan | | 2,136 | 6a · Vigorous |
| teeHuehuetla Tepehua | tee | Totonacan | | 1,500 | 6a · Vigorous |
| nazCoatepec Nahuatl | naz | Uto-Aztecan | | 1,400 | 7 · Shifting |
| seiSericmiique iitom | sei | Hoka-Sioux | | 900 | 6b · Threatened |
| nhvTemascaltepec Nahuatl | nhv | Uto-Aztecan | | 310 | 7 · Shifting |
| ctzZacatepec Chatino | ctz | Central American Indian languages | | 300 | 7 · Shifting |
| sacSac-Fox-Kickapoo | sac | Algic | | 250 | 8a · Moribund |
| afsAfro-Seminole Creole | afs | — | | 200 | 8a · Moribund |
| zoqAyapa Zoque | zoq | Mixe–Zoque | | 4 | 8b · Nearly Extinct |
| mamMam | mam | Central American Indian languages | | | 4 · Educational |
| lacLacandon | lac | Central American Indian languages | | | 5 · Developing |
| knjAkateko | knj | Central American Indian languages | | | 4 · Educational |
| chfChontal Maya | chf | Central American Indian languages | | | 6a · Vigorous |
| ttcTektitek | ttc | Central American Indian languages | | | 6b · Threatened |
| tojTojolab'al | toj | Central American Indian languages | | | 5 · Developing |
| apmMescalero-ChiricahuaNdee bizaa | apm | Na-Dene | | | 8a · Moribund |
| yaqYaqui | yaq | Uto-Aztecan | | | 8a · Moribund |
| mhcMocho’Qatoʼk | mhc | Central American Indian languages | | | 8a · Moribund |
| kicKickapoometotheeneniaatoweeheni | kic | Algic | | | 6b · Threatened |
| mazMazahua | maz | Central American Indian languages | | | 5 · Developing |
| aplLipan | apl | Na-Dene | | | 9 · Dormant |
| cobChicomuceltec | cob | Central American Indian languages | | | 9 · Dormant |
| cozChocho | coz | Central American Indian languages | | | 8b · Nearly Extinct |
| klbKiliwa | klb | Hoka-Sioux | | | 8b · Nearly Extinct |
| cocCocopah | coc | Hoka-Sioux | | | 7 · Shifting |
| ppiPaipai | ppi | Hoka-Sioux | | | 8a · Moribund |
| optOpata | opt | Uto-Aztecan | | | 10 · Extinct |
| mfsMexican Sign Language | mfs | — | | | 5 · Developing |
| tbuTubar | tbu | Uto-Aztecan | | | 10 · Extinct |
| cuyCuitlatec | cuy | — | | | 10 · Extinct |
| nlvOrizaba Nahuatl | nlv | Uto-Aztecan | | | 6a · Vigorous |
| piaPima Bajo | pia | Uto-Aztecan | | | 6b · Threatened |
| msdYucatec Maya Sign Language | msd | — | | | 6a · Vigorous |
| peiChichimeca Jonaz | pei | Central American Indian languages | | | 7 · Shifting |
| cojCochimí | coj | Hoka-Sioux | | | 9 · Dormant |
| ploOluta Popoluca | plo | Mixe–Zoque | | | 8b · Nearly Extinct |
| ocuTlahuica | ocu | Central American Indian languages | | | 8a · Moribund |
| vmzMazatlán Mazatec | vmz | — | | | 6a · Vigorous |
| cloHuamelula | clo | — | | | 8b · Nearly Extinct |
| cipChiapanec | cip | Central American Indian languages | | | 9 · Dormant |
| tepTepecano | tep | Uto-Aztecan | | | 10 · Extinct |
| zaqAloápam Zapotec | zaq | Central American Indian languages | | | 6a · Vigorous |
| trcCopala Triqui | trc | Central American Indian languages | | | 5 · Developing |
| otmEastern Highland Otomi | otm | Central American Indian languages | | | 5 · Developing |
| nclMichoacán Nahuatl | ncl | Uto-Aztecan | | | 6b · Threatened |
| zpoAmatlán Zapotec | zpo | Central American Indian languages | | | 5 · Developing |
| nhmMorelos Nahuatl | nhm | Uto-Aztecan | | | 6a · Vigorous |
| maqChiquihuitlán Mazatec | maq | Central American Indian languages | | | 6b · Threatened |
| zpcChoapan Zapotec | zpc | Central American Indian languages | | | 6b · Threatened |
| posSayula Popoluca | pos | Mixe–Zoque | | | 6b · Threatened |
| zplLachixío Zapotec | zpl | Central American Indian languages | | | 5 · Developing |
| zacOcotlán Zapotec | zac | Central American Indian languages | | | 6a · Vigorous |
| zarRincón Zapotec | zar | Central American Indian languages | | | 5 · Developing |
| ctaTataltepec Chatino | cta | Central American Indian languages | | | 6b · Threatened |
| miiChigmecatitlán Mixtec | mii | Central American Indian languages | | | 6b · Threatened |
| zamMiahuatlán Zapotec | zam | Central American Indian languages | | | 6b · Threatened |
| oteMezquital Otomi | ote | Central American Indian languages | | | 5 · Developing |
| majJalapa Mazatec | maj | Central American Indian languages | | | 6a · Vigorous |
| zooAsunción Mixtepec Zapotec | zoo | Central American Indian languages | | | 8b · Nearly Extinct |
| zohChimalapa Zoque | zoh | Mixe–Zoque | | | 6b · Threatened |
| chzChinantec of Ozumacín | chz | Central American Indian languages | | | 6b · Threatened |
| topPapantla Totonac | top | Totonacan | | | 5 · Developing |
| tosSierra Totonac | tos | Totonacan | | | 5 · Developing |
| otzIxtenco Otomi | otz | Central American Indian languages | | | 8a · Moribund |
| zpePetapa Zapotec | zpe | Central American Indian languages | | | 6b · Threatened |
| ztmSan Agustín Mixtepec Zapotec | ztm | Central American Indian languages | | | 8b · Nearly Extinct |
| zpmMixtepec Zapotec | zpm | Central American Indian languages | | | 5 · Developing |
| zpsSanto Domingo Coatlán Zapotec | zps | Central American Indian languages | | | 7 · Shifting |
| mxpTlahuitoltepec Mixe | mxp | Mixe–Zoque | | | 6a · Vigorous |
| tooXicotepec Totonac | too | Totonacan | | | 7 · Shifting |
| zpdYavesía Zapotec | zpd | Central American Indian languages | | | 6b · Threatened |
| zpqZoogocho Zapotec | zpq | Central American Indian languages | | | 6b · Threatened |
| zpgGuevea Zapotec | zpg | — | | | 5 · Developing |
| zttTejalapan Zapotec | ztt | Central American Indian languages | | | 8a · Moribund |
| vmyAyautla Mazatec | vmy | — | | | 5 · Developing |
| nhtOmetepec Náhuatl | nht | Uto-Aztecan | | | 7 · Shifting |
| chdHighland Oaxaca Chontal | chd | — | | | 8a · Moribund |
| amuGuerrero Amuzgo | amu | Central American Indian languages | | | 5 · Developing |
| zasAlbarradas Zapotec | zas | Central American Indian languages | | | 5 · Developing |
| chjChinantec of Ojitlán | chj | Central American Indian languages | | | 5 · Developing |
| cntChinantec of Tepetotutla | cnt | Central American Indian languages | | | 6a · Vigorous |
| pbfCoyotepec Popoloca | pbf | Central American Indian languages | | | 8a · Moribund |
| zppEl Alto Zapotec | zpp | Central American Indian languages | | | 6b · Threatened |
| tlpFilomeno Mata Totonac | tlp | Totonacan | | | 6a · Vigorous |
| tptTlachichilco Tepehua | tpt | Totonacan | | | 6b · Threatened |
| tppPisaflores Tepehua | tpp | Totonacan | | | 6a · Vigorous |
| tlcMisantla Totonac | tlc | Totonacan | | | 8a · Moribund |
| poqTexistepec Popoluca | poq | Mixe–Zoque | | | 8b · Nearly Extinct |
| mirIsthmus Mixe | mir | Mixe–Zoque | | | 5 · Developing |
| mziIxcatlán Mazatec | mzi | — | | | 6a · Vigorous |
| otsCentral Otomi | ots | Central American Indian languages | | | 5 · Developing |
| otlTilapa Otomi | otl | Central American Indian languages | | | 8a · Moribund |
| ztgXanaguía Zapotec | ztg | Central American Indian languages | | | 6a · Vigorous |
| zprXanica Zapotec | zpr | Central American Indian languages | | | 6b · Threatened |
| zpuYalálag Zapotec | zpu | Central American Indian languages | | | 5 · Developing |
| xtbChazumba Mixtec | xtb | Central American Indian languages | | | 8a · Moribund |
| xtuCuyamecalco Mixtec | xtu | Central American Indian languages | | | 6b · Threatened |
| mipApasco-Apoala Mixtec | mip | Central American Indian languages | | | 6b · Threatened |
| mxbTezoatlán Mixtec | mxb | Central American Indian languages | | | 5 · Developing |
| chqHighland Chinantec | chq | Central American Indian languages | | | 6a · Vigorous |
| nhcTabasco Nahuatl | nhc | Uto-Aztecan | | | 8b · Nearly Extinct |
| tqtOzumatlán Totonac | tqt | Totonacan | | | 6b · Threatened |
| csoSochiapam Chinantec | cso | Central American Indian languages | | | 5 · Developing |
| vmqSoyaltepec Mixtec | vmq | Central American Indian languages | | | 6b · Threatened |
| xttTacahua Mixtec | xtt | Central American Indian languages | | | 6b · Threatened |
| mtxTidaá Mixtec | mtx | Central American Indian languages | | | 6b · Threatened |
| mtuTututepec Mixtec | mtu | Central American Indian languages | | | 8a · Moribund |
| cvnValle Nacional Chinantec | cvn | Central American Indian languages | | | 7 · Shifting |
| cnlLalana Chinantec | cnl | Central American Indian languages | | | 5 · Developing |
| cutTeutila Cuicatec | cut | Central American Indian languages | | | 6b · Threatened |
| tacLowland Tarahumara | tac | Uto-Aztecan | | | 5 · Developing |
| cuxTepeuxila Cuicatec | cux | Central American Indian languages | | | 6a · Vigorous |
| pmqNorthern Pame | pmq | Central American Indian languages | | | 6b · Threatened |
| pbsCentral Pame | pbs | Central American Indian languages | | | 6a · Vigorous |
| mxyNuxaá Mixtec | mxy | Central American Indian languages | | | 6b · Threatened |
| zpbSan Bartolo Yautepec Zapotec | zpb | Central American Indian languages | | | 7 · Shifting |
| tcwTecpatlán Totonac | tcw | Totonacan | | | 6b · Threatened |
| hveSan Dionisio del Mar Huave | hve | — | | | 7 · Shifting |
| azzHighland Puebla Nahuatl | azz | Uto-Aztecan | | | 5 · Developing |
| nhkIsthmus-Cosoleacaque Nahuatl | nhk | Uto-Aztecan | | | 8a · Moribund |
| trqItunyoso Triqui | trq | Central American Indian languages | | | 6b · Threatened |
| tplTlacoapa Me'phaa | tpl | Central American Indian languages | | | 5 · Developing |
| nhzSanta María La Alta Nahuatl | nhz | Uto-Aztecan | | | 7 · Shifting |
| nhpIsthmus-Pajapan Nahuatl | nhp | Uto-Aztecan | | | 6b · Threatened |
| tlaSouthwestern Tepehuan | tla | Uto-Aztecan | | | 6a · Vigorous |
| tkuUpper Necaxa Totonac | tku | Totonacan | | | 6b · Threatened |
| azgSan Pedro Amuzgos Amuzgo | azg | Central American Indian languages | | | 6a · Vigorous |
| crnEl Nayar Cora | crn | Uto-Aztecan | | | 5 · Developing |
| hvvSanta Maria Del Mar Huave | hvv | — | | | 7 · Shifting |
| zocCopainalá Zoque | zoc | Mixe–Zoque | | | 6a · Vigorous |
| huvSan Mateo Del Mar Huave | huv | — | | | 5 · Developing |
| hueSan Francisco del Mar Huave | hue | — | | | 7 · Shifting |
| tpcAzoyú Me'phaa | tpc | Central American Indian languages | | | 8a · Moribund |
| tcfMalinaltepec Me'phaa | tcf | Central American Indian languages | | | 5 · Developing |
| zorRayón Zoque | zor | Mixe–Zoque | | | 7 · Shifting |
| tpxAcatepec Me'phaa | tpx | Central American Indian languages | | | 6a · Vigorous |
| tcuSoutheastern Tarahumara | tcu | Uto-Aztecan | | | 7 · Shifting |
| mauHuautla Mazatec | mau | Central American Indian languages | | | 6a · Vigorous |